Cross‐strand disulphides (CSDs) are unusual bonds that link adjacent strands in the same β‐sheet. Their peculiarity relates to the high potential energy stored in these bonds, both as torsional energy in the highly strained disulphide linkage and as deformation energy stored in the sheet itself. CSDs are relatively rare in protein structures but are conspicuous by their presence in proteins that are involved in cell entry. The finding that entry of botulinum neurotoxin and HIV into mammalian cells involves cleavage of (...) CSDs suggests that the activity of other cell entry proteins may likewise involve cleavage of these bonds. We examine emerging evidence of the involvement of these unusual disulphides in cell entry events. BioEssays 26:73–79, 2004. © 2003 Wiley Periodicals, Inc. (shrink)

\noindent\textbf{Introduction} Online interventions hold great potential for Therapeutic Change Process Research (TCPR), a field that aims to relate in-therapeutic change processes to the outcomes of interventions. Online a client is treated essentially through the language their counsellor uses, therefore the verbal interaction contains many important ingredients that bring about change. TCPR faces two challenges: how to derive meaningful change processes from texts, and secondly, how to assess these complex, varied and multi-layered processes? We advocate the use text mining and multi-level (...) models (MLMs): the former offers tools and methods to discovers patterns in texts; the latter can analyse these change processes as outcomes that vary at multiple levels. \noindent\textbf{Method} We (re-)used the data from \cite{Lamers2015} because it includes outcomes and the complete online intervention for clients with mild depressive symptoms. We used text mining to obtain basic text-variables from e-mails, that we analysed through MLMs. \noindent\textbf{Results} We found that we could relate outcomes of interventions to variables containing text-information. We conclude that we can indeed bridge text mining and MLMs for TCPR as it was possible to relate text-information (obtained through text mining) to multi-levelled TCPR outcomes (using a MLM). \noindent\textbf{Discussion} Text mining can be helpful to obtain change processes, which is also the main challenge for TCPR. We showed how MLMs and text mining can be combined, but our proposition leaves open how to obtain the most relevant textual operationalization of TCPR concepts. That requires interdisciplinary collaboration and discussion. The future does look bright: based on our proof-of-concept study we conclude that MLMs and text mining can indeed advance TCPR. (shrink)

There is a strong intuition that we can listen to works of music, yet musical ontologies on which works of music are abstract objects, perhaps most notably, type theories of music, seem to imply that this is impossible. This problem has received relatively little attention in the literature. I here explore and develop a solution suggested by Julian Dodd and argue that it has at least two problematic consequences, namely (i) that some works of music cannot be listened to unless (...) one has already studied the relevant score or through a similar process learned roughly what the work requires of its performances and (ii) that it is possible for two people to listen to different musical works while listening to the same performance. (shrink)

If climate change represents a severe threat to humankind, why then is response to it characterized by inaction at all levels? The authors argue there are two complementary explanations for the lack of motivation. First, our moral judgment system appears to be unable to identify climate change as an important moral problem and there are pervasive doubts about the agency of individuals. This explanation, however, is incomplete: Individual emitters can effectively be held morally responsible for their luxury emissions. Second, doubts (...) about individual agency have become overly emphasized and fail to convincingly exonerate individuals from responsibility. This book extends the second explanation for the motivational gap, namely that the arguments for the lack of individual agency do in fact correspond to mechanisms of moral disengagement. The use of these mechanisms enables consumption elites to maintain their consumptive lifestyles without having to accept moral responsibility for their luxury emissions. (shrink)

Fictional realists maintain that fictional characters are part of the world’s ontology. In an influential article, Anthony Everett argues that the fictional realist is thereby committing herself to problematic entities. Among these are entities that are indeterminately identical. Recently, Ross Cameron and Richard Woodward have answered Everett’s worry using the same strategy. They argue that the fictional realist can bypass the problematic identities by contending that they are merely semantically indeterminate. This paper concisely surveys Everett’s original argument, Cameron’s and Woodward’s (...) responses, and then argues that the strategy employed by Cameron and Woodward fails to satisfactorily answer Everett’s worries. (shrink)

Extensively updated to include clinical findings over the last two decades, this third edition of A Practitioner's Guide to Rational-Emotive Behavior Therapy reviews the philosophy, theory, and clinical practice of Rational Emotive Behavior Therapy. This model is based on the work of Albert Ellis, who had an enormous influence on the field of psychotherapy over his 50 years of practice and scholarly writing. Designed for both therapists-in-training and seasoned professionals, this practical treatment manual and guide introduces the basic principles of (...) rational-emotive behavior therapy, explains general therapeutic strategies, and offers many illustrative dialogues between therapist and patient. The volume breaks down each stage of therapy to present the exact procedures and skills therapists need, and numerous case studies illustrate how to use these skills. The authors describe both technical and specific strategic interventions, and they stress taking an integrative approach. The importance of building a therapeutic alliance and the use of cognitive, emotive, evocative, imaginal, and behavioral interventions serves as the unifying theme of the approach. Intervention models are presented for the treatment of anxiety, depression, trauma, anger, personality disorders, and addictions. Psychologists, clinical social workers, mental health counselors, psychotherapists, and students and trainees in these areas will find this book useful in learning to apply rational-emotive behavior therapy in practice. (shrink)

Lysophosphatidic acid (LPA) is a lipid mediator with a wide variety of biological actions, particularly as an inducer of cell proliferation, migration and survival. LPA binds to specific G‐protein‐coupled receptors and thereby activates multiple signal transduction pathways, including those initiated by the small GTPases Ras, Rho, and Rac. LPA signaling has been implicated in such diverse processes as wound healing, brain development, vascular remodeling and tumor progression. Knowledge of precisely how and where LPA is produced has long proved elusive. Excitingly, (...) it has recently been discovered that LPA is generated from precursors by ‘autotaxin’, a once enigmatic exo‐phosphodiesterase implicated in tumor cell motility. Exogenous phospholipases D can also produce LPA, which may contribute to their toxicity. Here we review recent progress in our understanding of LPA bioactivity, signaling and synthesis. BioEssays 26:870–881, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

It is well known that Carnap, early in his philosophical career, took most of metaphysics to consist of meaningless pseudostatements. In contrast to this meaning-theoretic critique of metaphysics, we develop what we take to be Carnap’s later value-based critique. We argue that this later critique is forceful against several central contemporary metaphysical debates, its origin in the principle of tolerance notwithstanding.

Comenius (1592 - 1670) war ein großer Europäer, ein kreativer Metaphysiker und überzeugter, aber nicht indoktrinierender Theologe, ein Pädagoge, der zugleich ein begnadeter Praktiker war, ein Politiktheoretiker, ein Literat und Linguist auf hohem Niveau. Der Wunsch, Gewalt von den Dingen fernzuhalten, stammt von ihm. Er wird verständlich, wenn man sich klar macht, dass Comenius „pansophisch“ (allumfassend) gedacht hat: Die Gewalt gegen die Dinge spiegelt die Gewalt gegen die Menschen, und beides muss aufhören. Die vorliegende Publikation zeigt eine fremde Welt, die (...) doch in unserer Zeit angesichts der Globalisierung aller Lebensbereiche wieder von großer Aktualität ist. Comenius fostered pansophic, all-encompassing thinking in philosophy, theology, history, politics and education. That is why today, in an age of increased globalisation, his works are the subject of renewed interest. Twenty-nine authors from eight countries, dedicated to this task, develop the picture of a great European thinker. (shrink)

Bovens and Hartmann (Bayesian Epistemology, Oxford: Oxford University Press, 2003) propose to analyze coherence as a confidence-boosting property. On the basis of this idea, they construct a new probabilistic theory of coherence. In this paper, I will attempt to show that the resulting measure of coherence clashes with some of the intuitions that motivate it. Also, I will try to show that this clash is not due to the view on coherence as a confidence-boosting property or to the general features (...) of the model that Bovens and Hartmann use to analyze coherence. It will turn out that there is at least one other measure that is similarly based on the concept of a confidence-boosting property, but does not have the same counterintuitive results. (shrink)

Bovens and Hartmann propose to analyze coherence as a confidence-boosting property. On the basis of this idea, they construct a new probabilistic theory of coherence. In this paper, I will attempt to show that the resulting measure of coherence clashes with some of the intuitions that motivate it. Also, I will try to show that this clash is not due to the view on coherence as a confidence-boosting property or to the general features of the model that Bovens and Hartmann (...) use to analyze coherence. It will turn out that there is at least one other measure that is similarly based on the concept of a confidence-boosting property, but does not have the same counterintuitive results. (shrink)

Deductivism is not merely a logical technique, but also a theory of normativity: it provides an objective and universal standard of evaluation. Contemporary dialectical logic rejects deductive normativity, replacing its universal standard by an intersubjective standard. It is argued in this paper that dialectical normativity does not improve upon deductive normativity. A dialogico-rhetorical alternative is proposed.

In this paper I consider whether there is a measure of coherence that could be rightly claimed to generalize the notion of logical equivalence. I show that Fitelson’s (2003) proposal to that effect encounters some serious difficulties. Furthermore, there is reason to believe that no mutual-support measure could ever be suitable for the formalization of coherence as generalized logical equivalence. Instead, it appears that the only plausible candidate for such a measure is one of relative overlap. The measure I propose (...) in this paper is quite similar to Olsson’s (2002) proposal but differs from it by not being susceptible to the type of counterexample that Bovens and Hartmann (2003) have devised against it. (shrink)

This book provides a novel formulation and defence of moral error theory. It also provides a novel solution to the so-called now what question; viz., the question what we should do with our moral thought and talk after moral error theory. The novel formulation of moral error theory uses pragmatic presupposition rather than conceptual entailment to argue that moral judgments carry a non-negotiable commitment to categorical moral reasons. The new answer to the now what question is pragmatic presupposition substitutionism: we (...) should substitute our current moral judgments, which pragmatically presuppose the existence of categorical moral reasons with ‘schmoral’ judgments that pragmatically presuppose the existence of a specific class of prudential reasons. These are prudential reasons that, when we act on them, contribute to the satisfaction of what the author calls ‘the fundamental desire’; namely, the desire to live in a world with mutually beneficial cooperation. (shrink)

ABSTRACT In this article, I will examine the question why it is so difficult to understand madness. First, I will examine what the third-person approach of psychosis or madness has to offer, and where its limitations lie with respect to its proper understanding. Next I will examine if and how the first-person perspective on madness contributes to our understanding. I will demonstrate that there is a stalemate between third- and first-person perspectives, which on the one hand hinders a free sight (...) on madness, but which is on the other hand exemplary of the problem that is presented by madness. This turns out to be a paradox that haunts both the concept and experience of madness itself, as well as those who try to understand it. In the fourth section, I will unpack some of the operations of the paradox as it is found both in philosophy and madness, both by their producers as by their consumers. In the fifth section, I will tentatively sketch (im)possibilities of escaping paradoxes. (shrink)

In this article, I examine the relation between philosophy and madness. It is often assumed that madness has to be suppressed, excluded, or conquered before a philosophically sensible text, logical argument, or world of meaning can appear. I argue, instead, that a certain concept of madness, when grafted on phenomenological psychiatry and philosophical mysticism, is intrinsically related to the project of philosophy. With the help of experiences of madness as presented in psychiatry and articulated in mad autobiographical reports, including my (...) own, I will show that philosophy and madness are in closer connection than is commonly assumed. In the introduction, I refer to some superficial... (shrink)

Although climate change jeopardizes the fundamental human rights of current as well as future people, current actions and ambitions to tackle it are inadequate. There are two prominent explanations for this motivational gap in the climate ethics literature. The first maintains that our conventional moral judgement system is not well equipped to identify a complex problem such as climate change as an important moral problem. The second explanation refers to people’s reluctance to change their behaviour and the temptation to shirk (...) responsibility. We argue that both factors are at play in the motivational gap and that they are complemented by crucial moral psychological insights regarding moral disengagement, which enables emitters to dissociate self-condemnation from harmful conduct. In this way, emitters are able to maintain their profligate, consumptive lifestyle, even though this conflicts with their moral standards with respect to climate change. We provide some illustrations of how strategies of moral disengagement are deployed in climate change and discuss the relationship between the explanations for the motivational gap and moral disengagement. On the basis of this explanatory framework, we submit that there are three pathways to tackle the motivational gap and moral disengagement in climate change: making climate change more salient to emitters and affirming their self-efficacy; reconsidering the self-interested motives that necessitate moral disengagement; and tackling moral disengagement directly. (shrink)

If coherence is to have justificatory status, as some analytical philosophers think it has, it must be truth-conducive, if perhaps only under certain specific conditions. This paper is a critical discussion of some recent arguments that seek to show that under no reasonable conditions can coherence be truth-conducive. More specifically, it considers Bovens and Hartmann’s and Olsson’s “impossibility results,” which attempt to show that coherence cannot possibly be a truth-conducive property. We point to various ways in which the advocates of (...) a coherence theory of justification may attempt to divert the threat of these results. (shrink)

Despite the Aristotelian renaissance in the philosophy of education, the development of virtue has not received much attention. This is unfortunate, because an attempt to draft an Aristotelian model of moral development can help philosophers to evaluate the contribution Aristotelian virtue ethics can make to our understanding of moral development, provide psychologists with a potentially richer account of morality and its development, and help educators to understand the developmental phase people are in. In the article, it is argued that the (...) Aristotelian categories of the ‘morally indifferent’, ‘un-self-controlled’, ‘self-controlled’ and ‘properly virtuous’ can be interpreted as the successive stages or levels of a comprehensive developmental model. For each stage, it will be made clear whether people are committed to virtue, whether they act virtuously or not, whether they act with pleasure or pain, and which desires and reasons they have for acting. The article closes with suggestions about what needs to be done if the proposed Aristotelian account of moral development is to become psychologically more realistic and educationally useful. (shrink)

This paper introduces and describes new protocols for proving knowledge of secrets without giving them away: if the verifier does not know the secret, he does not learn it. This can all be done while only using one-way hash functions. If also the use of encryption is allowed, these goals can be reached in a more efficient way. We extend and use the GNY authentication logic to prove correctness of these protocols.

This article addresses the need to problematize “cases” in science and technology studies work, as a middle-range theory issue. The focus is not on any one case study per se, but on why case studies exist and endure in STS. Case studies are part of a specific problematization in the field. We therefore explore relations between motivation for the use of cases, their constitution, and ways they can be invoked to make particular kinds of arguments in STS. We set out (...) to examine the case as an object that links together research practices, intellectual debates, and programmatic concerns in our own work. Based on our experiences and on this reflection on the links between cases and questions in STS, we propose a number of casemaking strategies that shift and enrich the deployment of ethnographic cases as an epistemic tool in STS. (shrink)

Full virtue and practical wisdom comprise the end of neo-Aristotelian moral development, but wisdom cannot be cultivated straight away through arguments and teaching. Wisdom is integrated with, and builds upon, habituation: the acquisition of virtuous character traits through the repeated practice of corresponding virtuous actions. Habit formation equips people with a taste for, and commitment to, the good life; furthermore it provides one with discriminatory and reflective capacities to know how to act in particular circumstances. Unfortunately, habituation is often understood (...) primarily as a method suitable only for children. This article examines whether Aristotle limited habituation to children and, if not, what the relationship between habituation and wisdom beyond childhood might look like. This article concludes that wisdom-guided habituation is also possible for adults who continue and confirm their already established virtuous habits. The implications of this for professional moral education are subsequently discussed. (shrink)

This paper reviews the debate on the notion of biological function and on functional explanation as this takes place in philosophy. It describes the different perspectives, issues, intuitions, theories and arguments that have emerged. The author shows that the debate has been too heavily influenced by the concerns of a naturalistic philosophy of mind and argues that in order to improve our understanding of biology the attention should be shifted from the study of intuitions to the study of the actual (...) practice of biological inquiry. (shrink)

In his Inleidinge tot de Hollandsche Rechts-geleerdheid, Hugo Grotius wrote an accessible introductory overview of Hollandic law, in which he combined insights from the learned law (ius commune) with the particular law of Holland. The Inleidinge was read by generations of Dutch law students, and would thus become very influential in the Roman-Dutch tradition. This contribution studies how the topic of representation, especially in a business context, was treated in Grotius’s Inleidinge. On the basis of an analysis of the Justinianic (...) Corpus iuris, the medieval ius commune tradition and – especially – early modern scholarship from the Low Countries, it is argued that Grotius’s Inleidinge by and large followed the communis opinio among the learned scholars, although on one important point – namely the acquisition by a third party of a claim on the basis of a stipulatio alteri – Grotius went beyond that communis opinio and, thus, opened the way for a gradual wider legal acceptance of active direct representation. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:How to Reason Beyond Reason? Toward a Philosophical Understanding of MadnessWouter Kusters, PhD (bio)To analyze the situation of madness on the ground, we need a grounded perspective, close to the situation at hand. The closer we come to the subject under scrutiny, the clearer its outlines, fine-grained details, and its dynamics, and the better we reach an explanation and understanding. The closer the approach, however, the higher the chances (...) are of becoming myopic and losing the connections with broader—or higher—perspectives: the view from above. It has been due to philosophical and historical approaches from above to the practices of philosophically inspired psychiatry that we may gain new insights into what is going on on the ground—and underground. This article by Garson provides such a view that may lead to a change in perspective, a new way to draw boundaries on the ground, to discover similarities and dissimilarities through space and time, without thereby losing the lived connection to the problematic ground.Garson proposes to replace a binary opposition of madness (in the sense of sick or insane) versus sanity (in the sense of healthy), with a triad of concepts, sanity, madness, and idiocy, taken from the work of philosophers of psychiatry avant la lettre in the early modern times, Locke, Kant, Wigan, and Heinroth. This triad is to be understood in terms of reason, where idiocy consists of the diminishment of some aspects of reason, while madness would be characterized by a perversion of reason. By examining how this perversion—or more neutrally said, this change—of reason was conceived by the four thinkers, Garson sheds a new light on research and theory within the philosophy of madness and the philosophy of psychiatry today. He examines the question of “how is it that the mad person “has” reason, but is still not reasonable?” with the help of the four authors mentioned above (of which I discuss three).In answering this question, Garson refers specifically to my work as an example of “exactly the kind of ontology we need for rethinking madness in a positive manner—not necessarily ‘positive’ in the sense of good, helpful, or ennobling, but in the sense of going beyond a mere lack, absence, or failure.” I wholeheartedly agree with this assessment, [End Page 317] and Garson’s proposal of this tripartite schema is helpful and valuable for thinking through how we can further nourish a positive view of madness, especially with reference to Mad Pride.Locke and HeinrothGarson discusses some fragments from Locke and concludes that according to Locke “the mad person, in contrast to the idiot, possesses reason by virtue of possessing an intact inferential capacity. What ultimately makes them mad, and not reasonable, is that their premises are flawed by the unhinged power of association.” So, with Locke the capacity for inferential logic is not disturbed, and in that sense reason is intact. The unreasonable behavior would be due, according to Locke, to an unbridled increase in imagination and associations, which are taken for reality. Instead of reason the capacity to align imagination and reality is afflicted. When we translate this Lockean view into contemporary terms, we could say that it is not their cognition, their way of processing stimuli that is problematic, but their being overwhelmed by impressions or stimuli. This is akin to “bottom-up” theories: Something is wrong with perception or experience, and ‘higher’ capacities of cognition and reasoning remain intact. Reason may seem ‘perverted,’ but at a closer look, this is a result of their being victim to anomalous experience, too many stimuli or too strong imaginations.Heinroth also explicitly distinguishes madness from idiocy, that is, from a diminishment of mental capacities. Instead, he considers madness as a reaction to what Garson calls “a reality that is too awful to bear.” Madness is then “a wholesome desire of nature to cure a perversion through another perversion.” Again, madness is then not in itself a diminishment of reason, but an attempt to cure something that went wrong, in a way that is also only seemingly wrong (perverted reason). Madness then is again within reason, but this core of intact reason is... (shrink)

In recent years, there has been an increasing interest in unethical work behavior. Several types of survey instruments to collect information about unethical work behavior are available. Nevertheless, to date little attention has been paid to design issues of those surveys. There are, however, several important problems that may influence reliability and validity of questionnaire data on the topic, such as social desirability bias. This paper addresses two important issues in the design of online surveys on unethical work behavior: the (...) response scale for questions regarding the frequency of certain types of unethical work behavior and the location of the background questions in an online survey. We present the results of an analysis of a double split-ballot experiment in a large sample (n = 3,386) on governmental integrity. We found that, when comparing response scales that have labels for all categories with response scales that only have anchors at the end, the latter provided answers with higher validity. The study did not provide support for the conventional practice of asking background questions at the end. (shrink)

The Random Number Generation task has a long history in neuropsychology as an assessment procedure for executive functioning. In recent years, understanding of human behavior has gradually changed from reflecting a static to a dynamic process and this shift in thinking about behavior gives a new angle to interpret test results. However, this shift also asks for different methods to process random number sequences. The RNG task is suited for applying non-linear methods needed to uncover the underlying dynamics of random (...) number generation. In the current article we present RandseqR: an R-package that combines the calculation of classic randomization measures and Recurrence Quantification Analysis. RandseqR is an easy to use, flexible and fast way to process random number sequences and readies the RNG task for current scientific and clinical use. (shrink)

I argue that there are at least four different ways in which the term ‘function’ is used in connection with the study of living organisms, namely: function as activity, function as biological role, function as biological advantage, and function as selected effect. Notion refers to what an item does by itself; refers to the contribution of an item or activity to a complex activity or capacity of an organism; refers to the value for the organism of an item having a (...) certain character rather than another; refers to the way in which a trait acquired and has maintained its current share in the population. The recognition of a separate notion of function as biological advantage solves the problem of the indeterminate reference situation that has been raised against a counterfactual analysis of function, and emphasizes the importance of counterfactual comparison in the explanatory practice of organismal biology. This reveals a neglected problem in the philosophy of biology, namely that of accounting for the insights provided by counterfactual comparison. (shrink)

ABSTRACT This paper aims to offer a new perspective on role modelling by examining adolescents’ own efforts to lead a morally virtuous life. While traditional approaches to moral education emphasize the importance of teachers as role models, this study proposes a shift in focus towards adolescents’ own role models. Drawing on the philosophical concept of moral self-cultivation and psychological insights on identity development and social cognitive learning, it is argued that adolescents have the ability to cultivate their moral character by (...) emulating others. However, empirical evidence suggests that adolescents often do not perceive teachers as their role models. Consequently, moral educational theories are advised to demand less of teachers as role models. Teachers could invest more time in understanding students’ personal role models and encourage them to compare these role models with their own behavior. By acknowledging and addressing students’ role models, teachers can facilitate the moral self-cultivation of adolescents. (shrink)

I argue that there are at least four different ways in which the term ‘function’ is used in connection with the study of living organisms, namely: function as activity, function as biological role, function as biological advantage, and function as selected effect. Notion refers to what an item does by itself; refers to the contribution of an item or activity to a complex activity or capacity of an organism; refers to the value for the organism of an item having a (...) certain character rather than another; refers to the way in which a trait acquired and has maintained its current share in the population. The recognition of a separate notion of function as biological advantage solves the problem of the indeterminate reference situation that has been raised against a counterfactual analysis of function, and emphasizes the importance of counterfactual comparison in the explanatory practice of organismal biology. This reveals a neglected problem in the philosophy of biology, namely that of accounting for the insights provided by counterfactual comparison. (shrink)

BACKGROUND: Delusions in schizophrenia are commonly approached as empirical false beliefs about everyday reality. Phenomenological accounts, by contrast, have suggested that delusions are more adequately understood as pertaining to a different kind of reality experience. How this alteration of reality experience should be characterised, which dimensions of experiential life are involved, and whether delusional reality might differ from standard reality in various ways is unclear and little is known about how patients with delusions value and relate to these experiential alterations. (...) This study aimed to investigate the nature of delusional reality experience, and its subjective apprehension, in individuals with lived experience of delusions and a schizophrenia-spectrum diagnosis. METHODS: In this qualitative phenomenological study, we recruited individuals with lived experience of delusions and a schizophrenia-spectrum diagnosis from two psychiatric-hospital services in Belgium using homogenous sampling. Criteria for participation were having undergone at least one psychotic episode with occurring delusional symptoms, present at least 1 year before participation, on the basis of clinical notes assessed by the attending psychiatrist; a schizophrenia-spectrum diagnosis, ascertained through clinical interview by the attending psychiatrist upon admission; being aged between 18 years and 65 years; and having the capacity to give informed consent. Exclusion criteria included worries concerning capacity to consent and risk of distress caused by participation. We did phenomenologically driven semi-structured interviews with the participants to explore the nature of delusional reality experience and their subjective valuation of these experiences. We used interpretative phenomenological analysis, a qualitative method tailored to the in-depth exploration of participants’ first-person perspective, to analyse their accounts. FINDINGS: Between March 2, 2020, and Sept 30, 2020, 18 adults participated in the interview study. The findings suggest that delusions are often embedded in wide-ranging alterations of basic reality experience, involving quasi-ineffable atmospheric and ontological qualities that undermine participants’ sense of the world as unambiguously real, fully present, and shared with others. We also found that delusional reality experience can differ from standard reality in various ways, across multiple dimensions, and that participants are often implicitly or explicitly aware of the distinction between delusional and standard reality. Delusional experience can have an enduring value and meaning that is not fully captured by a strictly medical perspective. INTERPRETATION: Increased awareness and recognition of the distinctive nature of delusional reality experience, in both clinical and research settings, can improve diagnostic accuracy, explanatory models, and therapeutic support for individuals with delusions whose lived realities are not always evident from an everyday perspective. FUNDING: FWO Flanders. TRANSLATION: For the Dutch translation of the abstract see Supplementary Materials section. (shrink)

This book provides a novel formulation and defence of moral error theory. It also provides a novel solution to the so-called now what question; viz., the question what we should do with our moral thought and talk after moral error theory. The novel formulation of moral error theory uses pragmatic presupposition rather than conceptual entailment to argue that moral judgments carry a non-negotiable commitment to categorical moral reasons. The new answer to the now what question is pragmatic presupposition substitutionism: we (...) should substitute our current moral judgments, which pragmatically presuppose the existence of categorical moral reasons with ‘schmoral’ judgments that pragmatically presuppose the existence of a specific class of prudential reasons. These are prudential reasons that, when we act on them, contribute to the satisfaction of what the author calls ‘the fundamental desire’; namely, the desire to live in a world with mutually beneficial cooperation. (shrink)

This paper is concerned with reasonings that purport to explain why certain organisms have certain traits by showing that their actual design is better than contrasting designs. Biologists call such reasonings 'functional explanations'. To avoid confusion with other uses of that phrase, I call them 'design explanations'. This paper discusses the structure of design explanations and how they contribute to scientific understanding. Design explanations are contrastive and often compare real organisms to hypothetical organisms that cannot possibly exist. They are not (...) causal but appeal to functional dependencies between an organism's different traits. These explanations point out that because an organism has certain traits, it cannot be alive if the trait to be explained were replaced by a specified alternative. They can be understood from a mechanistic point of view as revealing the constraints on what mechanisms can be alive. (shrink)

L’« effet un peu criant » produit par la juxtaposition qui constitue le concept d’a priori historique ne l’a pas empêché de devenir un concept directeur de l’« épistémologie historique », une orientation philosophique qui introduit la contingence historique au sein des « cadres infrangibles » qui structurent notre expérience. On peut identifier les travaux de cette tradition...

Abating the threat climate change poses to the lives of future people clearly challenges our development models. The 2011 Human Devel- opment Report rightly focuses on the integral links between sustainability and equity. However, the human development and capabilities approach emphasizes the expansion of people’s capabilities simpliciter, which is ques- tionable in view of environmental sustainability. We argue that capabilities should be defined as triadic relations between an agent, constraints and poss- ible functionings. This triadic syntax particularly applies to climate (...) change: since people’s lives and capabilities are dependent on the environment, sus- tainable human development should also include constraining human activi- ties in order to prevent losses in future people’s well-being due to the adverse effects of exacerbated climate change. On this basis, we will advocate that the goals of sustainable human development should be informed by a fra- mework that consists of enhancing capabilities up to a threshold level, as well as constraining the functionings beyond this threshold in terms of their green- house gas emissions. (shrink)

Climate change and other contemporary harms are often depicted as New Harms because they seem to constitute unprecedented challenges. This New Harms Discourse rests on two important premises, both of which we criticise on empirical grounds. First, we argue that the Premise of changed conditions of human interaction—according to which the conditions regarding whom people affect have changed recently and which emphasises the difference with past conditions of human interaction—risks obfuscating how humanity’s current predicament is merely the transient result of (...) long-term, gradual processes and developments. Second, we dispute the Premise that New Harms have certain features that render them new and argue that New Harms share characteristics with other harms. On the basis of these premises, the New Harms Discourse concludes that climate change is a unique social challenge that requires radically new moral thinking, but we argue that this Uniqueness Myth distracts attention from the valuable lessons we can draw from humanity’s successes and failures in dealing with past harms. We will illustrate how action to tackle climate change and other complex, systemic harms can be informed by the interdisciplinary study of historic harms. We will argue that rejecting the New Harms Discourse is not only empirically justified, it also gives cause for optimism, because it opens up the possibility to draw upon the past to face problems in the present and future. (shrink)